Impaired brain StAR and HSP70 gene expression in zebrafish exposed to Methyl-Parathion based insecticide.

Fish production ponds and natural water body areas located in close proximity to agricultural fields receive water with variable amounts of agrochemicals, and consequently, compounds that produce adverse effects may reach nontarget organisms. The aim of this study was to investigate whether waterborne methyl-parathion-based insecticide (MPBI) affected gene expression patterns of brain glucocorticoid receptor (GR), steroidogenic acute regulatory protein (StAR), and heat shock protein 70 (hsp70) in adult zebrafish (Danio rerio) exposed to this chemical for 96 h. Treated fish exposed to MPBI-contaminated water showed an inhibition of brain StAR and hsp70 gene expression. Data demonstrated that MPBI produced a decrease brain StAR and hsp70 gene expression.

Citation

João Gabriel Santos da Rosa, Gessi Koakoski, Angelo L Piato, Maurício Reis Bogo, Carla Denise Bonan, Leonardo José Gil Barcellos. Impaired brain StAR and HSP70 gene expression in zebrafish exposed to Methyl-Parathion based insecticide. Journal of toxicology and environmental health. Part A. 2016;79(1):1-7

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PMID: 26699931

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