Recruiting of insulator protein ZIPIC of Drosophila melanogaster to minor binding sites in vivo depends on other DNA-binding transcription factors].

N A Zolotarev, O V Kyrchanova, O G Maksimenko, P G Georgiev

Molekuliarnaia biologiia 2015 Nov-Dec

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ZIPIC insulator protein of Drosophila has seven zinc finger domains at the C-terminus. Some of this zinc fingers are involved in binding of specific DNA sequence: CAGGGCTG. ZIPIC can interact only in vivo with minor form of this site (substitution of G to T at position 4). Possible explanation is interaction with additional transcription factors can help ZIPIC to bind minor form of consensus. On the other hand ZIPIC can efficiently bind in vitro other minor form of consensus (substitution of C to A at 6 position).

Citation

N A Zolotarev, O V Kyrchanova, O G Maksimenko, P G Georgiev. Recruiting of insulator protein ZIPIC of Drosophila melanogaster to minor binding sites in vivo depends on other DNA-binding transcription factors]. Molekuliarnaia biologiia. 2015 Nov-Dec;49(6):1016-21