Maintaining K balance on the low Na, high K diet.

A low Na, high K diet (LNaHK) is considered a healthier alternative to the "Western" high Na diet. Because the mechanism for K secretion involves Na reabsorptive exchange for secreted K in the distal nephron, it is not understood how K is eliminated with such low Na intake. Animals on LNaHK produce an alkaline load, high urinary flows, and markedly elevated plasma angiotensin II (ANGII) and aldosterone (aldo) levels in order to maintain K balance. Recent studies have revealed a potential mechanism involving the actions of alkalosis, urinary flow, elevated ANGII, and aldo on two types of potassium channels, ROMK and BK, located in principal and intercalated cells. Here we review these recent advances. Copyright © 2015, American Journal of Physiology - Renal Physiology.

Citation

Ryan J Cornelius, Bangchen Wang, Jun Wang-France, Steven C Sansom. Maintaining K balance on the low Na, high K diet. American journal of physiology. Renal physiology. 2016 Jan 6:ajprenal.00330.2015

PMID: 26739887

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