The Interaction of Myc with Miz1 Defines Medulloblastoma Subgroup Identity.

BaoHan T Vo, Elmar Wolf, Daisuke Kawauchi, Anneli Gebhardt, Jerold E Rehg, David Finkelstein, Susanne Walz, Brian L Murphy, Yong Ha Youn, Young-Goo Han, Martin Eilers, Martine F Roussel

Cancer cell 2016 Jan 11

filter terms:

Four distinct subgroups of cerebellar medulloblastomas (MBs) differ in their histopathology, molecular profiles, and prognosis. c-Myc (Myc) or MycN overexpression in granule neuron progenitors (GNPs) induces Group 3 (G3) or Sonic Hedgehog (SHH) MBs, respectively. Differences in Myc and MycN transcriptional profiles depend, in part, on their interaction with Miz1, which binds strongly to Myc but not MycN, to target sites on chromatin. Myc suppresses ciliogenesis and reprograms the transcriptome of SHH-dependent GNPs through Miz1-dependent gene repression to maintain stemness. Genetic disruption of the Myc/Miz1 interaction inhibited G3 MB development. Target genes of Myc/Miz1 are repressed in human G3 MBs but not in other subgroups. Therefore, the Myc/Miz1 interaction is a defining hallmark of G3 MB development. Copyright © 2016 Elsevier Inc. All rights reserved.

Citation

BaoHan T Vo, Elmar Wolf, Daisuke Kawauchi, Anneli Gebhardt, Jerold E Rehg, David Finkelstein, Susanne Walz, Brian L Murphy, Yong Ha Youn, Young-Goo Han, Martin Eilers, Martine F Roussel. The Interaction of Myc with Miz1 Defines Medulloblastoma Subgroup Identity. Cancer cell. 2016 Jan 11;29(1):5-16