How dynein and dynactin transport cargos: a structural perspective.

Andrew P Carter, Aristides G Diamant, Linas Urnavicius

Current opinion in structural biology 2016 Apr

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Recent structures of the dynein motor in three different conformations reveal how it uses ATP hydrolysis to move along microtubules. Attention is now turning to how cytoplasmic dynein-1 and dynactin act together to carry cargos. Cryo-electron microscopy (cryo-EM) has revealed the structure of dynactin and how it binds dynein in the presence of a cargo adaptor protein Bicaudal-D2 (BICD2). Future questions will include how dynein-1 transports so many different cargos and how the 2.4MDa dynein/dynactin transport machine is regulated. Copyright © 2015 Elsevier Ltd. All rights reserved.

Citation

Andrew P Carter, Aristides G Diamant, Linas Urnavicius. How dynein and dynactin transport cargos: a structural perspective. Current opinion in structural biology. 2016 Apr;37:62-70