Biotransformation of patchoulol by Cunninghamella echinulata var. elegans.

Fangfang Xu, Kangsheng Liao, Yuhong Liu, Zhenbiao Zhang, Dean Guo, Ziren Su, Bo Liu

Fitoterapia 2016 Mar

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Biocatalysis of patchoulol (PA) was performed by the fungus Cunninghamella echinulata var. elegans. Eight metabolites (1-8) including four new compounds were obtained, and their structures were elucidated as (5R,8S)-5,8 dihydroxypatchoulol (1), (5R*,9R*)-5,9 dihydroxypatchoulol (2), (6S*, 9S*)-6,9 dihydroxypatchoulol (3), and (4R*)-4 hydroxypatchoulol (4) by spectroscopic analysis. The absolute configuration of 1 was determined by single crystal X-ray diffraction. Copyright © 2016 Elsevier B.V. All rights reserved.

Citation

Fangfang Xu, Kangsheng Liao, Yuhong Liu, Zhenbiao Zhang, Dean Guo, Ziren Su, Bo Liu. Biotransformation of patchoulol by Cunninghamella echinulata var. elegans. Fitoterapia. 2016 Mar;109:201-5