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The Drosophila mid-oogenesis stages are notable as the time when most maternal mRNAs become localized at discrete regions of the oocyte. Microtubule rearrangement occurs during this period and is critical for the localization of axis-determining maternal mRNAs. We have identified shot as a key player in establishing the cytoskeletal arrangement required for the spatial localization of axis-determining maternal mRNAs. We also found that the spatial distribution of the Shot protein is regulated by its mRNA localization. Our results suggest that the RNA localization mechanism is used not only for restricted accumulation of patterning molecules but also for the microtubule organization that leads to the initial development of oocyte polarity. © 2016 Federation of European Biochemical Societies.

Citation

Jiyeon Lee, Sujung Lee, Cheng Chen, Hyeran Shim, Jeongsil Kim-Ha. shot regulates the microtubule reorganization required for localization of axis-determining mRNAs during oogenesis. FEBS letters. 2016 Feb;590(4):431-44

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PMID: 26832192

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