Genome-wide association study of serum iron phenotypes in premenopausal women of European descent.

A genome-wide association study was performed on 1130 premenopausal women to detect common variants associated with three serum iron-related phenotypes. Total iron binding capacity was strongly associated (p=10(-14)) with variants in and near the TF gene (transferrin), the serum iron transporting protein, and with variants in HFE (p=4×10(-7)), which encodes the human hemochromatosis gene. Association was also detected between percent iron saturation (p=10(-8)) and variants in the chromosome 6 region containing both HFE and SLC17A2, which encodes a phosphate transport protein. No significant associations were detected with serum iron, but variants in HFE were suggestive (p=10(-6)). Our results corroborate prior studies in older subjects and demonstrate that the association of these genetic variants with iron phenotypes can be detected in premenopausal women. Copyright © 2015 Elsevier Inc. All rights reserved.

Citation

Daniel L Koller, Erik A Imel, Dongbing Lai, Leah R Padgett, Dena Acton, Amie Gray, Munro Peacock, Michael J Econs, Tatiana Foroud. Genome-wide association study of serum iron phenotypes in premenopausal women of European descent. Blood cells, molecules & diseases. 2016 Mar;57:50-3

PMID: 26852655

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