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The regulation and localization of the neuronal voltage gated Ca(2+) channel CaV1.2 is important for synaptic plasticity associated with learning and memory. The cytoskeletal protein, α-actinin-1 is known to interact with CaV1.2 and stabilize its localization at the postsynaptic membrane. Here we report both backbone and sidechain NMR assignments for the C-terminal EF-hands (EF3 and EF4) of α-actinin-1 (residues 824-892, called ACTN_EF34) bound to the IQ-motif (residues 1644-1665) from CaV1.2 (BMRB accession no. 25902).


Matthew Turner, David E Anderson, Sahana Rajan, Johannes W Hell, James B Ames. Chemical shift assignments of the C-terminal EF-hand domain of α-actinin-1. Biomolecular NMR assignments. 2016 Apr;10(1):219-22

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PMID: 26861220

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