Exploring the multifaceted nature of the common lymphoid progenitor compartment.

While the common lymphoid progenitor compartment was originally thought to be a rather homogenous cell population, it has become increasingly clear that this compartment is highly heterogeneous both with regard to phenotypic and functional features. The exploration of this cellular complexity has generated novel molecular insights into regulatory events in lymphoid lineage restriction and provided support for the idea that multiple lineage restriction events occur at this developmental stage. Furthermore, the identification of multiple lineage-restricted progenitors with mixed lineage potential challenges a strictly hierarchical model for lymphoid development. Instead we propose a model based on competence windows during which cell fates are established through the action of lineage determining factors. Copyright © 2016 Elsevier Ltd. All rights reserved.

Citation

Christina T Jensen, Tobias Strid, Mikael Sigvardsson. Exploring the multifaceted nature of the common lymphoid progenitor compartment. Current opinion in immunology. 2016 Apr;39:121-6

PMID: 26871596

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