A peptide hydrogel derived from a fragment of human cardiac troponin C.

Luis M De Leon-Rodriguez, Meder Kamalov, Yacine Hemar, Alok K Mitra, Valeria Castelletto, Daniel Hermida-Merino, Ian W Hamley, Margaret A Brimble

Chemical communications (Cambridge, England) 2016 Mar 14

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The human cardiac troponin C peptide fragment H-V(9)EQLTEEQKNEFKAAFDIFVLGA(31)-OH, which covers helix-A in the native protein, self-assembles into β-sheet fibrils in solution. These fibrils further entangle to give a hydrogel. This peptide may therefore serve as a template for development of novel biomaterials.

Citation

Luis M De Leon-Rodriguez, Meder Kamalov, Yacine Hemar, Alok K Mitra, Valeria Castelletto, Daniel Hermida-Merino, Ian W Hamley, Margaret A Brimble. A peptide hydrogel derived from a fragment of human cardiac troponin C. Chemical communications (Cambridge, England). 2016 Mar 14;52(21):4056-9