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HIV-1 Tat-interacting protein of 110kDa (Tip110), also referred to as squamous cell carcinoma antigen recognized by T cells 3 (Sart3), p110 or p110(nrb), was initially identified as a cDNA clone (KIAA0156) without annotated functions. Over the past twenty years, several functions have been attributed to this protein. The proposed biological functions include roles for Tip110 in pre-mRNA splicing, gene transcription, stem cell biology, and development. Dysregulation of Tip110 is also a contributing factor in the development of cancer and other human diseases. It is clear that our understanding of this protein is rapidly evolving. In this review, we aimed to provide a summary of all the existing literature on this gene/protein and its proposed biological functions. Copyright © 2016 Elsevier Inc. All rights reserved.

Citation

Amanda Whitmill, Khalid Amine Timani, Ying Liu, Johnny J He. Tip110: Physical properties, primary structure, and biological functions. Life sciences. 2016 Mar 15;149:79-95

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PMID: 26896687

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