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The hedgehog (Hh) signaling pathway is aberrantly activated in a majority of basal cell carcinomas (BCC). Vismodegib and sonidegib are targeted inhibitors of Smoothened (SMO). Both drugs are approved for use in locally advanced BCC (laBCC), with vismodegib also approved for metastatic BCC (mBCC). Copyright © 2016 Elsevier Inc. All rights reserved.
Citation
Aleksandar Sekulic, Daniel Von Hoff. Hedgehog Pathway Inhibition. Cell. 2016 Feb 25;164(5):831
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PMID: 26919418
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