The RNA Helicase eIF4A Is Required for Sapovirus Translation.

Myra Hosmillo, Trevor R Sweeney, Yasmin Chaudhry, Eoin Leen, Stephen Curry, Ian Goodfellow, Kyoung-Oh Cho

Journal of virology 2016 May 15

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The eukaryotic initiation factor 4A (eIF4A) is a DEAD box helicase that unwinds RNA structure in the 5' untranslated region (UTR) of mRNAs. Here, we investigated the role of eIF4A in porcine sapovirus VPg-dependent translation. Using inhibitors and dominant-negative mutants, we found that eIF4A is required for viral translation and infectivity, suggesting that despite the presence of a very short 5' UTR, eIF4A is required to unwind RNA structure in the sapovirus genome to facilitate virus translation. Copyright © 2016 Hosmillo et al.

Citation

Myra Hosmillo, Trevor R Sweeney, Yasmin Chaudhry, Eoin Leen, Stephen Curry, Ian Goodfellow, Kyoung-Oh Cho. The RNA Helicase eIF4A Is Required for Sapovirus Translation. Journal of virology. 2016 May 15;90(10):5200-5204