HLA-DMB in Amerindians: Specific linkage of DMB*01:03:01/DRB1 alleles.

HLA-DMB proteins are important for intracellular microbial metabolism in order other major histocompatibility complex (MHC) molecules present peptides to lymphocytes. In addition, HLA-DMB alleles have been found linked to diseases in some ethnic groups and HLA-DMB molecules may be important to explain HLA disease association. To detect HLA-DMB alleles profile in Amerindians for the first time and compare them to other populations. This will establish the bases to study HLA-DMB linkage to disease in Amerindians. A group of 168 voluntary Amerindians have been typed for HLA-DMB alleles. They have been characterized both, by genetic and genealogical bases. Cloning and automated HLA-DMB DNA (exons 2, 3 and 4) sequencing have been performed for allele assignation. HLA-DMB*01:01:01 and HLA-DMB*01:03:01 show the highest frequencies. These have been compared to other World wide populations. HLA-DMB*01:03:01 is tightly associated to certain specific HLA-DRB1 alleles in Amerindians. The specific Amerindian HLA-DMB allele frequencies and their linkage disequilibrium with other MHC alleles may be crucial to determine HLA-DMB World wide variation, evolution and specific linkage to disease in Amerindians and other populations. Copyright © 2016 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

Citation

Antonio Arnaiz-Villena, Jose Palacio-Grüber, Ester Muñiz, Diego Rey, Maria Jose Recio, Cristina Campos, Narcisa Martinez-Quiles, Jose Manuel Martin-Villa, Jorge Martinez-Laso. HLA-DMB in Amerindians: Specific linkage of DMB*01:03:01/DRB1 alleles. Human immunology. 2016 May;77(5):389-94

PMID: 26944519

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