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ARHGEF17 sets the timer for retention of Mps1 at kinetochores.
The Journal of cell biology 2016 Mar 14Sizes of these terms reflect their relevance to your search.
The kinetochore-associated kinase Mps1 controls the spindle assembly checkpoint, but the regulation of its kinetochore recruitment and activity is unclear. In this issue, Isokane et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201408089) show that interaction with and phosphorylation of its substrate, ARHGEF17, regulates Mps1 kinetochore retention, suggesting an autoregulated, timer-like mechanism. © 2016 Marquardt and Fisk.
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Joseph R Marquardt, Harold A Fisk. ARHGEF17 sets the timer for retention of Mps1 at kinetochores. The Journal of cell biology. 2016 Mar 14;212(6):615-6
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PMID: 26953355
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