Targeting the fatty acid transport protein CD36, a class B scavenger receptor, in the treatment of renal disease.

Hideki Yokoi, Motoko Yanagita

Kidney international 2016 Apr

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Augmentation of the CD36 pathway, which involves the uptake of several endogenous ligands including free fatty acids and oxidized low-density lipoprotein, contributes to the damage of proximal tubules and podocytes, whereas ablation of CD36 attenuates renal injury. Souza et al. demonstrate that 5A peptide can inhibit CD36 signaling, attenuate chronic kidney disease progression, and ameliorate inflammation and tubulointerstitial fibrosis by reducing the expression of inflammatory cytokines and chemokines, suggesting the therapeutic potential of 5A peptide against CD36-mediated renal injury. Copyright © 2016 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.

Citation

Hideki Yokoi, Motoko Yanagita. Targeting the fatty acid transport protein CD36, a class B scavenger receptor, in the treatment of renal disease. Kidney international. 2016 Apr;89(4):740-2