Delfly B Abdjul, Hiroyuki Yamazaki, Syu-ichi Kanno, Ohgi Takahashi, Ryota Kirikoshi, Kazuyo Ukai, Michio Namikoshi
Journal of natural products 2016 Apr 22Four new haliclonadiamine analogues, (10Z,12E)-haliclonadiamine (1), (10E,12Z)-haliclonadiamine (2), and halichondriamines A (3) and B (4), were isolated from the Okinawan marine sponge Halichondria panicea together with haliclonadiamine (5) and papuamine (6). The structures of 1-4 were elucidated on the basis of their spectroscopic data by comparisons with those for 5 and 6. Further separation of the remaining fraction led to the isolation of a new bicyclic guanidine alkaloid, 6-epi-monanchorin (7), along with monanchorin (8). Compound 7 is the epimer of 8 at the 6 position. Compounds 1-6 inhibited the growth of Mycobacterium smegmatis with inhibition zones of 12, 7, 8, 7, 16, and 12 mm at 10 μg/disc, respectively. Compounds 2-4 exhibited weak cytotoxicities against the Huh-7 (hepatoma) human cancer cell line and were 2-fold less active than 5 and 6. Compounds 7 and 8 were not active against M. smegmatis at 20 μg/disc or the cancer cell line at 10 μM.
Delfly B Abdjul, Hiroyuki Yamazaki, Syu-ichi Kanno, Ohgi Takahashi, Ryota Kirikoshi, Kazuyo Ukai, Michio Namikoshi. Haliclonadiamine Derivatives and 6-epi-Monanchorin from the Marine Sponge Halichondria panicea Collected at Iriomote Island. Journal of natural products. 2016 Apr 22;79(4):1149-54
PMID: 27035556
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