miR-100 suppresses the proliferation and tumor growth of esophageal squamous cancer cells via targeting CXCR7.

MicroRNAs are highly conserved non-coding RNAs that regulate gene expression at the post-transcriptional level, and play pivotal roles in cancer development and progression. miR-100 has been reported to be significantly downregulated in a variety of cancers, including esophageal cancer. However, the role of miR-100 in human esophageal cancer has not been fully elucidated. We demonstrated that overexpression of miR-100 in esophageal cancer cells markedly inhibited cell proliferation, migration and invasion as well as tumor growth. We subsequently showed that CXCR7 is a direct target gene of miR-100. Our results indicated that miR-100 plays a tumor-suppressor role in esophageal cancer and suggest its potential application for esophageal cancer treatment.

Citation

Shao-Mei Zhou, Fang Zhang, Xue-Bin Chen, Cao-Ming Jun, Xin Jing, Deng-Xiong Wei, Yang Xia, Yu-Bai Zhou, Xiang-Qian Xiao, Run-Qing Jia, Jing-Tao Li, Wang Sheng, Yi Zeng. miR-100 suppresses the proliferation and tumor growth of esophageal squamous cancer cells via targeting CXCR7. Oncology reports. 2016 Jun;35(6):3453-9

PMID: 27035873

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