Store-operated CRAC channel inhibitors: opportunities and challenges.

Aberrant Ca(2+) release-activated Ca(2+) (CRAC) channel activity has been implicated in a number of human disorders, including immunodeficiency, autoimmunity, occlusive vascular diseases and cancer, thus placing CRAC channels among the important targets for the treatment of these disorders. We briefly summarize herein the molecular basis and activation mechanism of CRAC channel and focus on discussing several pharmacological inhibitors of CRAC channels with respect to their biological activity, mechanisms of action and selectivity over other types of Ca(2+) channel in different types of cells.

Citation

Chengsen Tian, Lupei Du, Yubin Zhou, Minyong Li. Store-operated CRAC channel inhibitors: opportunities and challenges. Future medicinal chemistry. 2016 May;8(7):817-32

PMID: 27149324

search → result