Medicinal Attributes of Imidazo[1,2-a]pyridine Derivatives: An Update.

The imidazo[1,2-a]pyridine scaffold is recognized as a privileged structure and it represents a promising area for identification of lead structures towards the discovery of new synthetic drug molecules. Several marketed drugs such as Zolpidem (sedative), Olprinone (used in the heart failure), Soraprazan (antiulcer drug in phase II), and many other compounds in biological testing and preclinical evaluation, illustrate the wide therapeutic spectrum in this class of drug scaffolds. The present manuscript represents the assimilation of literature pertaining to medicinal aspects of this pharmacophore including the structure-activity relationships.

Citation

Nisha Devi, Dharmender Singh, Ravindra K Rawal, Jitender Bariwal, Virender Singh. Medicinal Attributes of Imidazo[1,2-a]pyridine Derivatives: An Update. Current topics in medicinal chemistry. 2016 May 6

PMID: 27150367

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