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Vaccine schedules including bivalent oral and inactivated poliovirus vaccines will replace trivalent oral poliovirus vaccines in 2016. We evaluated rotavirus immunoglobulin A seroresponses when the second dose of Rotarix at 16 weeks was given concomitantly with inactivated or bivalent oral poliovirus vaccines. Rotavirus immunoglobulin A seroresponse rate at week 28 was 15% lower in recipients of bivalent oral poliovirus vaccines compared with inactivated poliovirus vaccines. Bivalent oral poliovirus vaccine decreases rotavirus IgA seroresponse rates when coadministered at 16 weeks of age.


Sasirekha Ramani, Nora Mamani, Rodolfo Villena, Ananda S Bandyopadhyay, Chris Gast, Alicia Sato, Daniel Laucirica, Ralf Clemens, Mary K Estes, Miguel L O'Ryan. Rotavirus Serum IgA Immune Response in Children Receiving Rotarix Coadministered With bOPV or IPV. The Pediatric infectious disease journal. 2016 Oct;35(10):1137-9

PMID: 27254033

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