Expression Pattern of Matrix Metalloproteinase 20 (MMP20) in Human Tumors.

Matrix metalloproteinase 20 (MMP20) is a member of the family of matrix metalloproteinases. Under normal conditions the expression of MMP20 is restricted to ameloblasts and odontoblasts. In order to identify a possible expression of MMP20 under pathological conditions, we investigated three major human tumor entities, i.e. colon, breast and lung tumors, on the mRNA and protein level. Real-time RT-PCR and immunocytochemical analyses of established human tumor cell lines were employed for our study; immunohistochemical analysis was performed on both primary tumors and normal control tissues. MMP20 was identified on both the mRNA and the protein level in breast MCF-7, colon HT-29, and lung A549 cell lines. MMP20 was also detected in primary tumor tissue by immunohistochemistry. MMP20 is a new potential candidate for tumor diagnosis or therapy. Copyright© 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

Citation

Dominik Kraus, Jan Reckenbeil, Sven Perner, Jochen Winter, Rainer Probstmeier. Expression Pattern of Matrix Metalloproteinase 20 (MMP20) in Human Tumors. Anticancer research. 2016 Jun;36(6):2713-8

PMID: 27272780

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