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Dicer has been well studied in cancer; however, deciphering its exact function in tumorigenesis continues to be a challenge. While partial suppression or truncation of Dicer promotes tumorigenesis, its complete deletion inhibits tumor growth. Here, we discuss this Dicer cancer conundrum in the context of its recently discovered role in the DNA damage response.
Citation
Vijay Swahari, Ayumi Nakamura, Mohanish Deshmukh. The paradox of dicer in cancer. Molecular & cellular oncology. 2016 May;3(3):e1155006
PMID: 27314098
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