Correlation Engine 2.0
Clear Search sequence regions


Sizes of these terms reflect their relevance to your search.

Chemokines and chemokine receptors regulate multiple processes such morphogenesis, angiogenesis and immune responses. Among the chemokine receptors, CXCR4 stands out for its pleiotropic roles as well as for its involvement in several pathological conditions, including immune diseases, viral infections and cancer. For these reasons, CXCR4 represents a crucial target in drug development. In this review, we discuss of CXCR4 receptor properties and signaling in health and diseases, focusing on the WHIM syndrome, an inherited immunodeficiency caused by mutations of the CXCR4 gene. Copyright © 2016 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved.

Citation

Tommaso Pozzobon, Giacomo Goldoni, Antonella Viola, Barbara Molon. CXCR4 signaling in health and disease. Immunology letters. 2016 Sep;177:6-15

Expand section icon Mesh Tags

Expand section icon Substances


PMID: 27363619

View Full Text