Influence of Radiation Exposure During Radiotherapy. Evidence for the Increase of Versican and Heparin-Binding EGF-like Growth Factor Concentrations.

Mahmut Kemal Ozbilgin, Caner Aktas, Elgin Turkoz Uluer, Mustafa Cagatay Buyukuysal, Manuchehr Salehi Gareveran, Cengiz Kurtman

Analytical and quantitative cytopathology and histopathology 2016 Apr

filter terms:

To investigate the reaction of versican and heparin-binding EGF-like growth factor (HB-EGF) molecule concentrations to acute radiation exposure in normal bladder and rectal tissue samples in order to gain more insight into the effects of cancer radiotherapy. Four groups with 6 male adult Swiss Albino mice per group were investigated. The mice bladder and rectum tissue samples were subjected to a 10-Gy single-dose radiation exposure in the pelvic region with a Co-60 teletherapy device and investigated 1, 2, and 7 days after radiation exposure, with 1 reference group which was not exposed to radiation. In the immunohistochemical examination of the tissue samples with anti-versican and anti-HB-EGF primary antibodies was observed a statistically significant increase 7 days after radiation exposure. The observed increase of versican and HB-EGF concentrations in the normal tissue matrix after radiation exposure may play a role in the side effects of radiotherapy.

Citation

Mahmut Kemal Ozbilgin, Caner Aktas, Elgin Turkoz Uluer, Mustafa Cagatay Buyukuysal, Manuchehr Salehi Gareveran, Cengiz Kurtman. Influence of Radiation Exposure During Radiotherapy. Evidence for the Increase of Versican and Heparin-Binding EGF-like Growth Factor Concentrations. Analytical and quantitative cytopathology and histopathology. 2016 Apr;38(2):126-32