Sequential kidney-liver transplantation from the same living donor for lecithin cholesterol acyl transferase (LCAT) deficiency.

Lecithin cholesterol acyl transferase (LCAT) deficiency is a rare autosomal recessive disorder of lipoprotein metabolism that results in end stage renal disease (ESRD) necessitating transplantation. Since LCAT is produced in the liver, combined kidney and liver transplantation was proposed to cure the clinical syndrome of LCAT deficiency. A 29-year-old male with ESRD secondary to LCAT deficiency underwent a sequential kidney-liver transplantation from the same living donor. One year later, auxiliary partial orthotopic liver transplant (APOLT) of a left lateral segment from the same donor was performed. At five years follow-up, there have been no major complications, readmissions, or rejection episodes. Serum lipid abnormalities recurred within the first year, but liver and kidney allograft function remains intact. Few cases of sequential transplantation from the same living donor have been performed in adults. This is the first APOLT and multi-organ transplant done for LCAT deficiency. Sequential organ transplant from the same living donor for ESRD secondary to a metabolic disorder of the liver is feasible in adults and should be further investigated. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

Citation

Sarwat B Ahmad, Michael Miller, Steven Hanish, Stephen T Bartlett, William Hutson, Rolf N Barth, John C LaMattina. Sequential kidney-liver transplantation from the same living donor for lecithin cholesterol acyl transferase (LCAT) deficiency. Clinical transplantation. 2016 Aug 4

PMID: 27490864

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