CD301b(+) Mononuclear Phagocytes Maintain Positive Energy Balance through Secretion of Resistin-like Molecule Alpha.

Yosuke Kumamoto, Joao Paulo G Camporez, Michael J Jurczak, Marya Shanabrough, Tamas Horvath, Gerald I Shulman, Akiko Iwasaki

Immunity 2016 Sep 20

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Mononuclear phagocytes (MNPs) are a highly heterogeneous group of cells that play important roles in maintaining the body's homeostasis. Here, we found CD301b (also known as MGL2), a lectin commonly used as a marker for alternatively activated macrophages, was selectively expressed by a subset of CD11b(+)CD11c(+)MHCII(+) MNPs in multiple organs including adipose tissues. Depleting CD301b(+) MNPs in vivo led to a significant weight loss with increased insulin sensitivity and a marked reduction in serum Resistin-like molecule (RELM) α, a multifunctional cytokine produced by MNPs. Reconstituting RELMα in CD301b(+) MNP-depleted animals restored body weight and normoglycemia. Thus, CD301b(+) MNPs play crucial roles in maintaining glucose metabolism and net energy balance. Copyright © 2016 Elsevier Inc. All rights reserved.

Citation

Yosuke Kumamoto, Joao Paulo G Camporez, Michael J Jurczak, Marya Shanabrough, Tamas Horvath, Gerald I Shulman, Akiko Iwasaki. CD301b(+) Mononuclear Phagocytes Maintain Positive Energy Balance through Secretion of Resistin-like Molecule Alpha. Immunity. 2016 Sep 20;45(3):583-596