One-pot synthesis of (-)-Ambrox.

Ambrox is recognised as the prototype of all ambergris odorants. Widely used in perfumery, (-)-Ambrox is an important ingredient due to its unique scent and excellent fixative function. An environmentally friendly and practical preparation of (-)-Ambrox is still unavailable at present although a lot of attention has been paid to this hot research topic for many years. A one-pot synthesis of (-)-Ambrox was studied starting from (-)-sclareol through oxidation with hydrogen peroxide in the presence of a quaternary ammonium phosphomolybdate catalyst {[C5H5NC16H33] [H2PMo12O40]}, which gave the product a 20% overall yield.

Citation

Shaoxiang Yang, Hongyu Tian, Baoguo Sun, Yongguo Liu, Yanfeng Hao, Yanyu Lv. One-pot synthesis of (-)-Ambrox. Scientific reports. 2016;6:32650

PMID: 27581945

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