Programmed necrosis: a new target for
ischemia reperfusion injury].

Recent years, the researchers have found a new type of cell death, referred to programmed necrosis or necroptosis, which involves the death receptor and the ligand binds and is initiated under the inhibition of apoptosis pathway. Programmed necrosis possesses the morphological features of typical necrosis accompanied by inflammation. The receptor interacting protein kinase 1/3(RIPK1/3) can be inhibited by the specific inhibitors, such as necrostatin-1. RIPK1/3 could regulate programmed necrosis and play a key role in the process. The significance of programmed necrosis in ischemia-reperfusion injury (IRI) has been attracted great attention at present. Simultaneously, a series of studies have found it also involves in the IRI of heart, kidney, brain and retina.

Citation

Xiaojing Li, Yingzi Ming, Ying Niu, Qianwen Liu, Qifa Ye. Programmed necrosis: a new target for
ischemia reperfusion injury]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. 2016 Jul;41(7):765-70

PMID: 27592584

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