NHERF1 in Microvilli of Vomeronasal Sensory Neurons.

Bastian Henkel, Willem Bintig, S Sneha Bhat, Marc Spehr, Eva M Neuhaus

Chemical senses 2017 Jan

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In most mammals, the vomeronasal system detects a variety of (semio)chemicals that mediate olfactory-driven social and sexual behaviors. Vomeronasal chemosensation depends on G protein-coupled receptors (V1R, V2R, and FPR-rs) that operate at remarkably low stimulus concentrations, thus, indicating a highly sensitive and efficient signaling pathway. We identified the PDZ domain-containing protein, Na+/H+ exchanger regulatory factor-1 (NHERF1), as putative molecular organizer of signal transduction in vomeronasal neurons. NHERF1 is a protein that contains 2 PDZ domains and a carboxy-terminal ezrin-binding domain. It localizes to microvilli of vomeronasal sensory neurons and interacts with V1Rs. Furthermore, NHERF1 and Gαi2 are closely colocalized. These findings open up new aspects of the functional organization and regulation of vomeronasal signal transduction by PDZ scaffolding proteins. © The Author 2016. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Citation

Bastian Henkel, Willem Bintig, S Sneha Bhat, Marc Spehr, Eva M Neuhaus. NHERF1 in Microvilli of Vomeronasal Sensory Neurons. Chemical senses. 2017 Jan;42(1):25-35