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The identification and characterization of male germ cell-specific genes is crucial to understanding the mechanisms of male germ cell development. In this study, we investigated the protein encoded by the novel mouse germ cell-specific gene testis-expressed gene 13 (Tex13). We found that TEX13 expression is testis- and germ cell-specific and is regulated in a stage-specific manner via translational repression. Immunostaining of testicular cells and sperm showed that TEX13 is localized in the nuclei of spermatogenic cells and the redundant nuclear envelope of mature sperm. Remarkably, we found that TEX13 possesses transcriptional repressor activity and that its overexpression in GC-2 cells altered the expression levels of 130 genes. Our results suggest that TEX13 has a potential role in transcriptional regulation during spermatogenesis. © 2016 Federation of European Biochemical Societies.

Citation

Jun Tae Kwon, Sora Jin, Heejin Choi, Jihye Kim, Juri Jeong, Jaehwan Kim, Chunghee Cho. TEX13 is a novel male germ cell-specific nuclear protein potentially involved in transcriptional repression. FEBS letters. 2016 Oct;590(20):3526-3537

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PMID: 27670266

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