Tip60: Main Functions and Its Inhibitors.

Xiaoli Zhang, Jiyong Wu, Yepeng Luan

Mini reviews in medicinal chemistry 2017

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Tip60, the founding member of MYST histone acetyltransferase family, was originally identified as a cellular acetyltransferase protein that interacts with HIV-1 Tat. Tip60 plays roles in many processes such as cellular signaling transmission, DNA damage repair, cell cycle and checkpoint control and apoptosis by acetylating its histone or non-histone substrates. Dysfunction of Tip60 could promote or suppress diseases including different kinds of cancers. Here, main functions and its known inhibitors were summarized. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.