Synthesis of amino ester-embedded benzimidazoles: a one-pot sequential protocol under metal-free neutral conditions.

Priyabrata Roy, Chandan Bodhak, Animesh Pramanik

Molecular diversity 2017 Feb

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A one-pot three-component protocol has been developed for the synthesis of amino ester-embedded benzimidazoles under metal-free neutral conditions. Sequentially, the methodology involves coupling of an amino ester with 1-fluoro-2-nitrobenzene, reduction of the coupled nitroarene by sodium dithionite, and cyclization of the corresponding diamine with an aldehyde.

Citation

Priyabrata Roy, Chandan Bodhak, Animesh Pramanik. Synthesis of amino ester-embedded benzimidazoles: a one-pot sequential protocol under metal-free neutral conditions. Molecular diversity. 2017 Feb;21(1):89-100