Nucleolar Methyltransferase Fibrillarin: Evolution of Structure and Functions.

M Y Shubina, Y R Musinova, E V Sheval

Biochemistry. Biokhimiia 2016 Sep

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Fibrillarin is one of the most studied nucleolar proteins. Its main functions are methylation and processing of pre-rRNA. Fibrillarin is a highly conserved protein; however, in the course of evolution from archaea to eukaryotes, it acquired an additional N-terminal glycine and arginine-rich (GAR) domain. In this review, we discuss the evolution of fibrillarin structure and its relation to the functions of the protein in prokaryotes and eukaryotes.

Citation

M Y Shubina, Y R Musinova, E V Sheval. Nucleolar Methyltransferase Fibrillarin: Evolution of Structure and Functions. Biochemistry. Biokhimiia. 2016 Sep;81(9):941-50