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    A green fluorescent protein (GFP)-tagged pepper mottle virus (PepMoV) based leaf-disc method and systemic host method were developed to identify antiviral agents. Preliminary experiments using a PepMoV-GFP based leaf-disc method led to the isolation of five quassinoids, including brusatol (1), bruceantin (2), brucein A (3), bruceantinol (4), and brucein B (5), from the CH3OH extract of Brucea javanica. All isolated compounds exhibited inactivation effects in systemic host plants, and compounds 3 and 4 were potent, with a minimum inhibitory concentration of 10μM. Furthermore, compound 3 was found to have a protective effect at the tested concentration of 40μM. Copyright © 2016 Elsevier B.V. All rights reserved.


    Seung Mok Ryu, Jaeyoung Kwon, Young Hye Seo, Eun Gyeong Song, Seong Su Hong, Beom Seok Kim, Jin Sung Hong, Ki Hyun Ryu, Dongho Lee. Quassinoids isolated from Brucea javanica inhibit pepper mottle virus in pepper. Virus research. 2017 Jan 02;227:49-56

    PMID: 27686478

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