Gastrin-releasing peptide receptor mediates the excitation of preoptic GABAergic neurons by bombesin.

Karine Blais, Jasmine Sethi, Iustin V Tabarean

Neuroscience letters 2016 Oct 28

filter terms:

Bombesin, a pan agonist of the bombesin-like peptide receptor family, elicits potent hypothermia when applied centrally. The signaling mechanisms involved are not known. Here we report that GABAergic preoptic neurons express gastrin-releasing peptide (GRP) receptors and are directly excited by GRP or bombesin. This effect was abolished by a GRP receptor antagonist. A partially overlapping group of preoptic GABAergic neurons express bombesin-like receptor 3 (BRS3), however their activation results in a decrease in firing rate. The excitatory effects of bombesin or GRP were not affected by BRS3 antagonist. GRP activated a Ca2+-dependent inward nonselective cationic current and Ca2+ release from intracellular stores. Our data indicate that GRP receptors mediate the excitatory effects of bombesin in preoptic neurons. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Citation

Karine Blais, Jasmine Sethi, Iustin V Tabarean. Gastrin-releasing peptide receptor mediates the excitation of preoptic GABAergic neurons by bombesin. Neuroscience letters. 2016 Oct 28;633:262-267