Organization of the axon initial segment: Actin like a fence.

What prevents the movement of membrane molecules between axonal and somatodendritic domains is unclear. In this issue, Albrecht et. al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201603108) demonstrate via high-speed single-particle tracking and superresolution microscopy that lipid-anchored molecules in the axon initial segment are confined to membrane domains separated by periodically spaced actin rings. © 2016 Huang and Rasband.

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Yu-Mei Huang, Matthew N Rasband. Organization of the axon initial segment: Actin like a fence. The Journal of cell biology. 2016 Oct 10;215(1):9-11

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PMID: 27697921

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