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    Selective C-H bond activation and functionalization is an invaluable and eco-friendly tool for new chemical bond construction. Recently, great progress has been made in the highly selective ortho- and meta-C-H bond functionalization of arene derivatives. In contrast, the remote para-C-H bond functionalization still remains a challenge. Herein, an oxidation-induced strategy for para-selective C-H bond functionalization of iodobenzenes towards the synthesis of various useful asymmetric diaryl ethers was demonstrated. This strategy not only provides a novel method for para-C-H bond functionalization, but also proposes a general idea for the development of new, highly selective para-C-H functionalization reactions.


    Ying Zhao, Haiming Yan, Hanwei Lu, Zhiliang Huang, Aiwen Lei. para-Selective C-H bond functionalization of iodobenzenes. Chemical communications (Cambridge, England). 2016 Sep 15;52(76):11366-11369

    PMID: 27709205

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