Dried Blood Spot Thyroglobulin as a Biomarker of Iodine Status in Pregnant Women.

The Journal of clinical endocrinology and metabolism 2017 Jan 01

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Thyroglobulin (Tg) could be a sensitive biomarker of iodine nutrition in pregnant women (PW). A dried blood spot (DBS) assay would simplify collection and transport in field studies. Our aims were to (1) establish and test a reference range for DBS-Tg in PW; (2) determine whether co-measurement of Tg antibodies (Abs) is necessary to define population iodine status. Standardized cross-sectional studies of 3870 PW from 11 countries. For the DBS-Tg reference range, we included TgAb-negative PW (n = 599) from 3 countries with sufficient iodine intake. We measured the urinary iodine concentration and DBS thyroid-stimulating hormone, total thyroxin, Tg, and TgAb. In the reference population, the median DBS-Tg was 9.2 μg/L (95% confidence interval, 8.7 to 9.8 μg/L) and was not significantly different among trimesters. The reference range was 0.3 to 43.5 μg/L. Over a range of iodine intake, the Tg concentrations were U-shaped. Within countries, the median DBS-Tg and the presence of elevated DBS-Tg did not differ significantly between all PW and PW who were TgAb-negative. A median DBS-Tg of ∼10 μg/L with <3% of values ≥44 μg/L indicated population iodine sufficiency. Concurrent measurement of TgAb did not appear necessary to assess the population iodine status.

Citation

Sara Stinca, Maria Andersson, Sandra Weibel, Isabelle Herter-Aeberli, Ralph Fingerhut, Sueppong Gowachirapant, Sonja Y Hess, Nidhi Jaiswal, Tomislav Jukic, Zvonko Kusic, Ngoako Solomon Mabapa, Ashwini Kumar Nepal, Teofilo O L San Luis, Jia Qing Zhen, Michael Bruce Zimmermann. Dried Blood Spot Thyroglobulin as a Biomarker of Iodine Status in Pregnant Women. The Journal of clinical endocrinology and metabolism. 2017 Jan 01;102(1):23-32