Correlation Engine 2.0
Clear Search sequence regions

  • control groups (2)
  • fibroblast (1)
  • human (2)
  • male (1)
  • random (1)
  • rat (6)
  • rats wistar (1)
  • simvastatin (8)
  • Sizes of these terms reflect their relevance to your search.

    We aimed to investigate whether simvastatin had any impact on the prevention of adhesion formation after thyroidectomy in a rat model. This study was performed in 66 Wistar albino rats randomized into three experimental groups. A right hemithyroidectomy was carried out in all the rats. Simvastatin was administered locally at a dose of 0.5 mg/kg and 0.8 mg/kg. Control rats received a saline solution only. Changes during the 1st week, 1st month and 3rd month were evaluated. Efficacy of the treatment was assessed by using a scoring system. The severity of adhesions in low-dose simvastatin group was significantly less than the control and high-dose groups during the 1st and 3rd month (p < .05). In addition, adhesions were less in the high dose group during the 3rd month, when compared to the control group (p < .05). Moreover, fibrosis and fibroblast scores, which represent adhesions, were significantly lower in low-dose and high-dose groups at 3rd month, compared to controls (p < .05). We investigated the influence of simvastatin application on post-thyroidectomy adhesion formation in rats. Whether adhesions, causing technical difficulties during neck redo surgery, can be reduced by the use of simvastatin in human, needs to be studied.


    Ozer Makay, Dilek Isik, Varlik Erol, Cigdem Yenisey, Timur Kose, Gokhan Icoz, Yesim Ertan, Omer Ozutemiz, Mahir Akyildiz. Efficacy of simvastatin in reducing postoperative adhesions after thyroidectomy: an experimental study. Acta chirurgica Belgica. 2017 Apr;117(2):77-83

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 27735220

    View Full Text