Correlation Engine 2.0
Clear Search sequence regions

  • cells (2)
  • daf 1 (1)
  • daf 3 (1)
  • daf 4 (1)
  • daf 5 (1)
  • daf 7 (1)
  • germ cells (2)
  • growth factor (2)
  • impairment (1)
  • male (3)
  • meiosis (1)
  • sperm (2)
  • spermatids (2)
  • spermatogenesis (6)
  • triazoles (2)
  • Sizes of these terms reflect their relevance to your search.

    There is increasing evidence that epoxiconazole exposure can affect reproductive function, but few studies have investigated adverse effects on spermatogenesis. The nematode Caenorhabditis elegans (C. elegans) was used in our study to assess effects of epoxiconazole on spermatogenesis in male nematodes after 48 h of exposure to concentrations of 0.1, 1.0, or 10.0 μg/L. The results demonstrated that epoxiconazole exposure affected spermatogenesis, decreasing the number of total germ cells, mitotic cells, meiotic cells and spermatids, spermatid diameter, and cross-sectional area, and inducing mitotic germ cell proliferation arrest, premature entry into meiosis, and sperm activation inhibition; however, sperm transfer showed no abnormal changes. In addition, the results showed that epoxiconazole activated the transforming growth factor-β (TGFβ) signaling pathway and increased the expression levels of gene daf-1, daf-3, daf-4, daf-5 and daf-7 in nematodes. We therefore propose that epoxiconazole acts by activating the TGFβ signaling pathway, leading to the impairment of spermatogenesis and the consequent decline in male fertility.


    Yunhui Li, Minhui Zhang, Shaojun Li, Rongrong Lv, Pan Chen, Ran Liu, Geyu Liang, Lihong Yin. The Use of the Nematode Caenorhabditis elegans to Evaluate the Adverse Effects of Epoxiconazole Exposure on Spermatogenesis. International journal of environmental research and public health. 2016 Oct 08;13(10)

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 27740608

    View Full Text