Examination of Potential Exceptions to the F and S Biosynthetic Classification of Fused-Ring Aromatic Polyketides.

The reported acetate-derived labelling of the fungal naphthalene γ-pyrone fonsecin, two streptomycete dodecaketide αpyrones TW93f and TW93g, and the streptomycete phenanthraquinones piloquinone, murayaquinone and haloquinone appear to be exceptions to the generalisation that fungi and streptomycetes produce fused-ring aromatic polyketides by different modes of cyclisation. A review of their 1) originally assigned formulae, 2) [13 C2 ]acetate-derived labelling patterns, and 3) modes of cyclisation leads to the recognition of feasible alternative chemical structures or biosynthetic pathways, which are in accord with the originally proposed classification system. © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Citation

Robert Thomas. Examination of Potential Exceptions to the F and S Biosynthetic Classification of Fused-Ring Aromatic Polyketides. Chembiochem : a European journal of chemical biology. 2016 Dec 02;17(23):2208-2215

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PMID: 27753463

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