When naive mice receive short Zfra peptides via tail vein injections, they develop lifetime resistance to growth of many cancer xenografts, due to activation of a novel spleen memory Hyal-2+ CD3- CD19- Z lymphocyte. In vitro education of spleen cells with Zfra activates Z cell for conferring memory anticancer response in vivo.
Wan-Pei Su, Wan-Jan Wang, Chun-I Sze, Nan-Shan Chang. Zfra induction of memory anticancer response via a novel immune cell. Oncoimmunology. 2016;5(9):e1213935
PMID: 27757310
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