Regulation of gene expression in human cancers by TRIM24.

Srikanth Appikonda, Kaushik N Thakkar, Michelle Craig Barton

Drug discovery today. Technologies 2016 Mar

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Tripartite Motif-containing protein 24 (TRIM24) functions as an E3 ligase targeting p53 for ubiquitination, a histone 'reader' that interacts with a specific signature of histone post-translational modifications and a co-regulator of nuclear receptor-regulated transcription. Although mouse models of Trim24 depletion suggest that TRIM24 may be a liver-specific tumor suppressor, several studies show that human TRIM24 is an oncogene when aberrantly over expressed. This review focuses on the mechanisms of TRIM24 functions in oncogenesis and metabolic reprogramming, which underlie recent interest in therapeutic targeting of aberrant TRIM24 in human cancers. Copyright © 2016 Elsevier Ltd. All rights reserved.

Citation

Srikanth Appikonda, Kaushik N Thakkar, Michelle Craig Barton. Regulation of gene expression in human cancers by TRIM24. Drug discovery today. Technologies. 2016 Mar;19:57-63