Post-translational modifications of FOXO family proteins (Review).

Ziyao Wang, Tinghe Yu, Ping Huang

Molecular medicine reports 2016 Dec

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The Forkhead box O (FOXO) protein family is predominantly involved in apoptosis, oxidative stress, DNA damage/repair, tumor angiogenesis, glycometabolism, regulating life span and other important biological processes. Its activity is affected by a variety of posttranslational modifications (PTMs), including phosphorylation, acetylation, ubiquitination, methylation and glycosylation. When cells are subjected to different environments, the corresponding PTMs act on the FOXO protein family, to change transcriptional activity or subcellular localization, and the expression of downstream target genes, will ultimately affect the biological behavior of the cells. In this review, we will discuss the biological characteristics of FOXO protein PTMs.

Citation

Ziyao Wang, Tinghe Yu, Ping Huang. Post-translational modifications of FOXO family proteins (Review). Molecular medicine reports. 2016 Dec;14(6):4931-4941