Cu2+-labeled dansyl compounds as fluorescent and PET probes for imaging apoptosis.

Compound DNSTT-Cu2+, a novel chelate of Cu2+ with DOTA conjugated to a fluorescent dansyl fragment, is developed for imaging cell apoptosis. Apoptotic U-87MG cells could be selectively visualized by the fluorescence of DNSTT-Cu2+ from cytoplasm of cells, confirmed by the fluorescence of apoptosis cells co-labeled with Alexa Fluor 568-labeled annexin V, a conventional probe for selectively labeling membranes of apoptosis cells. A radioactive 64Cu2+ analog, DNSTT-64Cu2+, was easily synthesized, providing a potential PET probe for imaging apoptosis in vivo. Copyright © 2016 Elsevier Ltd. All rights reserved.

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Junyan Han, Xukui Wang, MeiXiang Yu. Cu2+-labeled dansyl compounds as fluorescent and PET probes for imaging apoptosis. Bioorganic & medicinal chemistry letters. 2016 Nov 15;26(22):5594-5596

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PMID: 27780640

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