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Pulsed Dendritic Cells for the Therapy of Experimental Glioma.
I V Chekhonin, O I Gurina, S A Cherepanov, M A Abakumov, K P Ionova, D K Zhigarev, A V Makarov, V P Chekhonin
Bulletin of experimental biology and medicine 2016 Oct
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We obtained the morphologically, cytofluorometrically, and functionally mature dendritic cells from rats that were pulsed with antigens of the C6 glioma tissue extract. The concentrations of angiogenesis antigens (VEGF, VEGFR-1, and VEGFR-2) and periglioma zone proteins (GFAP, connexin 43, and BSAT1) in the pulsing extract were measured by ELISA. Our results drove us to a conclusion that despite mature phenotype of pulsed dendritic cell, the antigenic composition of glioma tissue extracts should be modified.
Citation
I V Chekhonin, O I Gurina, S A Cherepanov, M A Abakumov, K P Ionova, D K Zhigarev, A V Makarov, V P Chekhonin.
Pulsed Dendritic Cells for the Therapy of Experimental Glioma.
Bulletin of experimental biology and medicine.
2016 Oct;161(6):792-796
Mesh Tags
Animals
Antigens, CD
Antigens, Neoplasm
Brain Chemistry
Brain Neoplasms
Cell Differentiation
Cell Proliferation
Complex Mixtures
Connexin 43
Dendritic Cells
Gene Expression Regulation
Glial Fibrillary Acidic Protein
Glioma
Humans
Immunophenotyping
Neoplasm Transplantation
Organic Cation Transport Proteins
Primary Cell Culture
Rats
Stereotaxic Techniques
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factor Receptor-1
Vascular Endothelial Growth Factor Receptor-2
Substances
Antigens, CD
Antigens, Neoplasm
Complex Mixtures
Connexin 43
Glial Fibrillary Acidic Protein
Organic Cation Transport Proteins
Slco1c1 protein, rat
Vascular Endothelial Growth Factor A
connexin 43 protein, rat
vascular endothelial growth factor A, rat
Kdr protein, rat
Vascular Endothelial Growth Factor Receptor-1
Vascular Endothelial Growth Factor Receptor-2
PMID: 27783297
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