Serum uromodulin predicts graft failure in renal transplant recipients.

Dominik Steubl, Matthias Block, Victor Herbst, Wolfgang Schlumberger, Andreas Nockher, Susanne Angermann, Christoph Schmaderer, Uwe Heemann, Lutz Renders, Jürgen Scherberich

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2017 Mar

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Test the ability of serum uromodulin concentrations 1-3 months after renal transplantation to predict all-cause mortality (ACM) and graft loss (GL) in 91 patients. uromodulin predicted GL equivalently to the other markers studied: the risk for GL was reduced by 0.21 per one standard deviation (SD) increase (cystatin C: hazard ratio [HR] 4.57, creatinine: HR 4.53, blood-urea-nitrogen [BUN]: HR 2.50, estimated glomerular filtration rate [eGFR]: HR 0.10). In receiver-operating-characteristic (ROC) analysis, uromodulin predicted GL with an area-under-the curve of 0.782 at an optimal cut-off (OCO) of 24.0 ng/ml with a sensitivity of 90.0% and a specificity of 70.2%. Serum uromodulin predicted GL equivalently compared to conventional biomarkers of glomerular filtration.

Citation

Dominik Steubl, Matthias Block, Victor Herbst, Wolfgang Schlumberger, Andreas Nockher, Susanne Angermann, Christoph Schmaderer, Uwe Heemann, Lutz Renders, Jürgen Scherberich. Serum uromodulin predicts graft failure in renal transplant recipients. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 2017 Mar;22(2):171-177