The effect of pregnancy-specific β1-glycoprotein 1 on the transcription factor FOXP3 expression by immunocompetent cells.

S A Zamorina, L S Litvinova, K A Yurova, N A Dunets, O G Khaziakhmatova, V P Timganova, M S Bochkova, P V Khramtsov, M B Rayev

Doklady. Biochemistry and biophysics 2016 Sep

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The role of human pregnancy-specific β1-glycoprotein (PSG) in the regulation of expression of the transcription factor FOXP3 was studied. It is found that, under conditions of directed induction of phenotypic changes in CD4+ lymphocytes to regulatory T cells (Treg), PSG at high concentrations (10 and 100 μg/mL) increased FOXP3 expression. The evaluation of the spontaneous expression level of FOXP3 mRNA showed that PSG (1 and 100 μg/mL) stimulated the expression of this factor in mononuclear cells and isolated CD4+ lymphocytes. Thus, PSG stimulates FOXP3 expression in immunocompetent cells.

Citation

S A Zamorina, L S Litvinova, K A Yurova, N A Dunets, O G Khaziakhmatova, V P Timganova, M S Bochkova, P V Khramtsov, M B Rayev. The effect of pregnancy-specific β1-glycoprotein 1 on the transcription factor FOXP3 expression by immunocompetent cells. Doklady. Biochemistry and biophysics. 2016 Sep;470(1):361-363